EPR spectrometer for measuring CMA (cellular metabolic activity) and accessoriesRead more...Jan 30th 2023, 1:58 PM EST - Commodity Codes: UNSPSC 4110 Laboratory and scientific equipment
OCR and ECAR rates are key indicators of mitochondrial respiration and glycolysis and these measurements provide a systems-level view of cellular metabolic function in cultured cells and ex-vivo samples.2.
Cellular (in vitro) metabolic systems are widely used throughout the pharmaceutical industry to assist with the identification of whether or not a NCE has sufficient stability to be active when administered to an animal model or human - to identify likely candidates to take forward for further evaluation as potentially useful experimental drugs.
Mitochondria play a central role in cellular metabolism including heme, fatty acid, and steroid synthesis; metabolic cell signaling; oxidative phosphorylation; Ca2+ homeostasis; and apoptosis. Mitochondrial toxicity is one of major mechanisms of chemicals in organ toxicity, including the heart, nerves, muscles, pancreas, kidneys, and liver.
Mitochondria play a central role in cellular metabolism including heme, fatty acid, and steroid synthesis; metabolic cell signaling; oxidative phosphorylation; Ca2+ homeostasis; and apoptosis. Mitochondrial toxicity is one of major mechanisms of chemicals in organ toxicity, including the heart, nerves, muscles, pancreas, kidneys, and liver.
NCI uses fluorescence to identify the type of cell, while Raman is used to quantify lipids and other biomolecules as a function of their location within the cells and create metabolic imaging maps. NCI hypothesizes that cellular composition will reflect the malignancy of the cell and plan to develop methodologies to identify the type of cell based upon their chemical composition from within the complex microenvironment.
Therefore, a sensitive measurement of the media flux can be used to determine rates of cellular metabolism with great precision and in a totally non-invasive, label-free manner. Agilent Seahorse XF metabolic analyzers is the only commercially sole source instruments for pre-clinical research that in a microplate, in real time. This acquisition is one of major equipment as shared working horse with array of other instruments in UOB.
