NOTICE OF INTENT TO SOLE SOURCE: Automated Flow Cytometry Assay Preparation System

expired opportunity(Expired)
From: Federal Government(Federal)
started - 16 Aug, 2022 (1 month ago)

Start Date

16 Aug, 2022 (1 month ago)
due - 16 Aug, 2022 (1 month ago)

Due Date

30 Aug, 2022 (26 days ago)
Bid Notification

Opportunity Type

Bid Notification
NB644020-22-02490

Opportunity Identifier

NB644020-22-02490
COMMERCE, DEPARTMENT OF

Customer / Agency

COMMERCE, DEPARTMENT OF
ACQUISITION MANAGEMENT DIVISION 100 BUREAU DR.  GAITHERSBURG , MD 20899  USA

Location

ACQUISITION MANAGEMENT DIVISION 100 BUREAU DR. GAITHERSBURG , MD 20899 USA
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Contract Opportunity General Information Classification Description Attachments/Links Contact Information History Award Notices Follow NOTICE OF INTENT TO SOLE SOURCE: Automated Flow Cytometry Assay Preparation System Active Contract Opportunity Notice ID NB644020-22-02490 Related Notice Department/Ind. Agency COMMERCE, DEPARTMENT OF Sub-tier NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY Office DEPT OF COMMERCE NIST General Information View Changes Contract Opportunity Type: Special Notice (Updated)All Dates/Times are: (UTC-04:00) EASTERN STANDARD TIME, NEW YORK, USA Updated Published Date: Aug 16, 2022 11:55 am EDT Original Published Date: Aug 16, 2022 11:53 am EDTUpdated Response Date: Aug 30, 2022 09:00 am EDT Original Response Date: Aug 30, 2022 09:00 am EDTInactive Policy: 15 days after response date Updated Inactive Date: Original Inactive Date: Initiative: None Classification Original Set Aside: Product Service Code: NAICS Code: 334516 - Analytical Laboratory Instrument ManufacturingPlace of Performance: Description View Changes The National Institute of Standards and Technology (NIST) intends to negotiate on a sole source basis, under the authority of FAR 13.106-1(b) (1), with: Curiox Biosystems Inc., 400 W Cummings Park STE 4350, Woburn, Massachusetts 01801-7211 The sole source justification is based on the following: The Biomarker and Genomic Sciences Group within Biosystems and Biomaterials Division at the National Institute of Standards and Technology (NIST) needs to acquire an automated flow cytometry assay preparation system to accelerate high-throughput flow workflow without centrifuge steps for suspension cells and/or beads. The instrument will use fully automated liquid handling system to transfer antibodies and buffers which can minimize assay manual pipetting errors and inter-user variability. The automated Flow Cytometry Assay Preparation System is critical for reproducibility and productivity using flow cytometry assay when characterizing cells and quantitative measuring antibodies and cytokines in human or murine samples. This project is part of the NIST program in Engineering Biology and Quantitative Flow Cytometry. In response to the COVID-19 pandemic, NIST developed the quantitative bead-based flow cytometric serology assay and surrogate neutralization assay. This work made a significant impact on the development of the first and second WHO international reference panels for anti-SARS-CoV2 immunoglobulin, as well as the human SARS-CoV-2 serology standards through multiple inter-laboratory studies. An automated flow sample preparation system is critical for assay reproducibility and productivity, especially for large sample sizes. NIST entered into a Cooperative Research and Development Agreement (CRADA) with Curiox Biosystems Inc in 2021. As part of the CRADA, NIST was provided a Laminar WashTM HT2000 plus AUTO 1000. The goal of the CRADA was to develop automated, reproducible, and high-throughput SARS-CoV-2 serology and neutralization assays. Since receiving the equipment, NIST has spent approximately 900 scientific labor hours conducting serology assay experiments and developing new cell characterization assays. During the CRADA period, NIST has worked closely with Curiox Biosystems to improve the performance of this instrument, updated software programs, and made the system more compatible with the assays needed for the projects. NIST has tested the automated protocols and optimized our assay conditions to adapt to this system. The system has helped NIST significantly accelerate assay workflows of high-volume clinical samples through the development of fully automated sample preparation protocols. To maintain continuity and consistency of the serology assays and develop new cell characterization assays, NIST requires the same system. No other instruments will allow the continuation of ongoing studies and would set NIST research significantly back as detailed above. To prevent further delays in research efforts, as well as additional time and costs from incurring, it is recommended that a sole source award be made to Curiox Biosystems Inc. to purchase an automated flow cytometry assay preparation system. The resulting purchase order will be a Firm Fixed Price purchase order. The NAICS Code is 334516- Analytical Laboratory Instrument Manufacturing with a size standard of 1000 employees. No solicitation package will be issued. This notice of intent is not a request for competitive quotations; however, interested parties who regard themselves as capable of fulfilling these requirements are invited to submit responses to the Government for consideration. Responses received by 9:00 Am EST August 30, 2022, will be considered by the Government. Responses must be submitted via email to the Government point of contacts listed below. A determination by the Government not to compete the proposed acquisition based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Attachments/LinksNo attachments or links have been added to this opportunity. Contact Information View Changes Contracting Office Address ACQUISITION MANAGEMENT DIVISION 100 BUREAU DR. GAITHERSBURG , MD 20899 USA Primary Point of Contact Sadaf Afkhami Sadaf.Afkhami@nist.gov Phone Number 3019753976 Secondary Point of Contact Donald Graham Donald.Graham@nist.gov Phone Number 3019758567 HistoryAug 16, 2022 11:55 am EDTSpecial Notice (Updated)Aug 16, 2022 11:53 am EDTSpecial Notice (Original)

Dates

Start Date

16 Aug, 2022 (1 month ago)

Due Date

30 Aug, 2022 (26 days ago)

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Location

Country : United StatesState : Maryland