Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)

Document Type:Grants NoticeFunding Opportunity Number:PAR-23-281Funding Opportunity Title:Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)Opportunity Category:DiscretionaryOpportunity Category Explanation: Funding Instrument Type:GrantCategory of Funding Activity:EducationHealthCategory Explanation: Expected Number of Awards: CFDA Number(s):93.393 -- Cancer Cause and Prevention Research 93.394 -- Cancer Detection and Diagnosis Research 93.395 -- Cancer Treatment Research 93.396 -- Cancer Biology ResearchCost Sharing or Matching Requirement:No Version:Synopsis 1Posted Date:Aug 18, 2023Last Updated Date:Aug 18, 2023Original Closing Date for Applications:Sep 07, 2026 Current Closing Date for Applications:Sep 07, 2026 Archive Date:Oct 13, 2026Estimated Total Program Funding: Award Ceiling: Award Floor: Document Type:Grants NoticeFunding Opportunity Number:PAR-23-281Funding Opportunity Title:Research Projects to

Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)Opportunity Category:DiscretionaryOpportunity Category Explanation: Funding Instrument Type:GrantCategory of Funding Activity:EducationHealthCategory Explanation: Expected Number of Awards: CFDA Number(s):93.393 -- Cancer Cause and Prevention Research 93.394 -- Cancer Detection and Diagnosis Research 93.395 -- Cancer Treatment Research 93.396 -- Cancer Biology ResearchCost Sharing or Matching Requirement:No Version:Synopsis 1Posted Date:Aug 18, 2023Last Updated Date:Aug 18, 2023Original Closing Date for Applications:Sep 07, 2026 Current Closing Date for Applications:Sep 07, 2026 Archive Date:Oct 13, 2026Estimated Total Program Funding: Award Ceiling: Award Floor: Eligible Applicants:Special district governments Independent school districts For profit organizations other than small businesses State governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled "Additional Information on Eligibility" for clarification) Public housing authorities/Indian housing authorities Private institutions of higher education County governmentsAdditional Information on Eligibility:Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. Agency Name:National Institutes of HealthDescription:Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationallyLink to Additional Information:https://grants.nih.gov/grants/guide/pa-files/PAR-23-281.htmlGrantor Contact Information:If you have difficulty accessing the full announcement electronically, please contact: NIH Grants Information grantsinfo@nih.govSee Section VII. Agency Contacts within the full opportunity announcement for all other inquires.